Dr. Jayesh Gori

Surgical Oncologist

Risk Factors For Endometrial Cancer : A Complete Guide

Before we delve into the details of endometrial cancer, let’s begin with a brief overview of the female reproductive system and the role of the endometrium.

The female reproductive system is designed to carry out several functions, including producing female sex hormones, producing female sex cells (eggs), providing a nurturing environment for a fertilized egg to develop into a fetus, and supporting childbirth.

A critical part of this system is the uterus, a pear-shaped organ where a baby grows during pregnancy. The inner lining of the uterus is called the endometrium.

During the menstrual cycle, the endometrium thickens in preparation for potential pregnancy. If pregnancy doesn’t occur, this lining sheds — a process known as menstruation.

Endometrial cancer develops when the cells in the endometrium begin to grow out of control. These cells can then invade nearby tissues or spread to other parts of the body, a process known as metastasis.

If left untreated, endometrial cancer can have severe consequences. It can interfere with the normal function of the uterus and other nearby organs, such as the bladder or rectum.

In advanced stages, it can spread to distant organs like the lungs or liver, which can be life-threatening.

It’s worth noting that endometrial cancer is often detected at an early stage because it frequently produces abnormal vaginal bleeding, which prompts women to see their doctors.

If caught early, removing the uterus surgically often cures endometrial cancer. But if it’s not detected early, or if it comes back after treatment, more aggressive treatments may be needed, and survival rates can be lower.

Endometrial Cancer Risk Factors

Risk Factors For Endometrial Cancer

Endometrial cancer, also known as uterine cancer, is a type of cancer that starts in the lining of the uterus. Several factors can increase the risk of developing this disease.

Age and Menopause

The risk of endometrial cancer increases with age, particularly during and after menopause. Most cases of endometrial cancer occur in women aged 50 and over. Hormonal changes during menopause can contribute to the development of endometrial cancer.

Obesity and Sedentary Lifestyle

Obesity is a strong risk factor for endometrial cancer. Excess body fat can lead to an overproduction of estrogen, a hormone that can promote the growth of endometrial cancer cells.

Regular physical activity can help maintain a healthy body weight and reduce the risk of endometrial cancer.

Hormonal Imbalances

Hormonal imbalances, particularly those involving estrogen and progesterone, can increase the risk of endometrial cancer. Conditions that increase the body’s estrogen levels, such as polycystic ovary syndrome, can contribute to this risk.

Diabetes and Insulin Resistance

Individuals with diabetes or insulin resistance have a higher risk of developing endometrial cancer. These conditions can cause hormonal imbalances that promote the growth of endometrial cancer cells.

Family History and Genetics

A family history of endometrial cancer or certain genetic conditions, like Lynch syndrome, can significantly increase a person’s risk of developing this disease.

Reproductive Factors

Certain reproductive factors can influence the risk of endometrial cancer. These include early menstruation (before age 12), late menopause (after age 55), having never given birth, and infertility.

Understanding these risk factors can help individuals take proactive steps to reduce their risk of endometrial cancer. It’s important to discuss these risks with your doctor, who can provide personalized advice based on your individual circumstances.

Lifestyle Modifications for Risk Reduction

Adopting a healthier lifestyle can play a significant role in reducing the risk of endometrial cancer and other health conditions. Here are some practical tips to consider:

Balanced Diet

A balanced and nutritious diet is key to maintaining a healthy weight and hormonal balance. Here are some tips:

  • Protein-rich foods: Include enough protein in every meal. Protein provides essential amino acids that your body needs but can’t produce itself.
  • Fruits, vegetables, and whole grains: These foods are high in fiber and can help regulate your hormones while keeping you feeling full and satisfied.
  • Healthy fats: Foods like avocados, fatty fish, and olive oil can provide you with healthy fats, which are essential for hormone production.
  • Limit caffeine and alcohol: Both can negatively impact your hormonal balance and overall health.

Regular Exercise

Regular physical activity can help maintain a healthy weight and lower the risk of endometrial cancer.

Aim for at least 30 minutes of moderate-intensity exercise, like brisk walking, on most days of the week. Remember, any physical activity is better than none.

Diabetes Management

If you have diabetes or insulin resistance, managing your condition effectively can reduce your risk of endometrial cancer.

This involves regular monitoring of your blood sugar levels, eating a balanced diet, exercising regularly, and following medication advice.

Hormonal Balance

Maintaining hormonal balance is crucial for overall health. A balanced diet, regular exercise, and adequate sleep are all essential for hormone regulation. If you suspect a hormonal imbalance, consult your doctor for advice.

Knowing Family History

Knowing your family’s medical history can help identify if you’re at a higher risk of certain diseases, including endometrial cancer. If endometrial cancer runs in your family, share this information with your oncologist.

Birth Control and Hormone Replacement Therapy

Hormonal interventions, such as birth control pills or hormone replacement therapy, can sometimes reduce the risk of endometrial cancer.

However, these options also come with potential risks and side effects. Always discuss these with your Endometrial Cancer Doctor to fully understand the benefits and risks.

Remember, these are general guidelines, and individual needs may vary. Always consult with a qualified Endometrial Cancer surgeon in Mumbai before making significant changes to your diet or lifestyle.

Expertise in Endometrial Cancer (uterine Cancer)Treatment

“Take control of your health and explore our comprehensive endometrial cancer treatment in Mumbai options at SSO Hospital. Schedule a consultation today. know more our expert endometrial Surgeon will guide you towards a brighter, cancer-free future.”


Your health should always be a priority. Regular health screenings and check-ups are an essential part of this, helping to ensure that any potential issues are caught early and treated effectively.

So, don’t wait for symptoms to arise – take proactive steps today to safeguard your health and well-being. Make informed choices, stay vigilant about any changes in your body, and consult with endometrial cancer specialists regularly for optimal health.