Aggressive cervical neuroblastoma with a rare paraneoplastic syndrome: A therapeutic dilemma

By: Dr. Jay Mehta
Authors: Qureshi SS, Bhagat M, Vora T2.
Journal: Journal of Indian Association of Pediatric Surgeons
Category: Parotid and Thyroid Surgeries
Start: July 19, 2016
DOI: 10.4103/0971-9261.186548


Neuroblastoma is infrequently associated with paraneoplastic syndromes. Amongst the few, opsomyoclonus (Kinsbourne syndrome) is the most common neurological paraneoplastic syndrome and diarrhea secondary to increased secretion of vasoactive intestinal peptide (Kerner-Morrison syndrome), hormonal paraneoplastic syndrome.

Hypothalamic dysfunction (HD) is a rare disorder and its manifestation as a paraneoplastic syndrome of neuroblastoma is uncommonly reported. We present an interesting case of an unrelenting cervical neuroblastoma associated with HD, which posed a therapeutic challenge.

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